Dianabol (Methandrostenolone) the first anabolic steroid

Dianabol has an anabolic-androgenic ratio of 90-210:40-60 and has the molecular weight of 300.44 g/mol at the base.Dianabol may be detected in the urine sample usually via gas chromatography-mass spectrometry. Primary urinary metabolites of Dianabol can be detected for up to 4 days, and hydroxymethyl metabolite can be found in urine for up to 19 days after a single 5mg oral dose. The chemical name of Dianabol is [17a-methyl-17b-hydroxy-1,4-androstadien-3-one] and its molecular formula is C20H28O2.

Dianabol has the ability of stimulating dramatic and nearly-permanent improvements in terms of muscle strength, muscle function and size, glycogenolysis, and protein synthesis. This anabolic androgenic steroid can easily pass through the liver and only a small part of this steroid gets broken down because of 17α-methylation of Dianabol. This means Dianabol can even be used by athletes who are prone to liver toxicity when using oral steroids.

Dianabol has been extremely popular among amateur and professional bodybuilders and some of the most eminent names to have accepted its use include Arnold Schwarzenegger, Ronnie Coleman, and Phil Heath. Dianabol is best used at the start of a steroid cycle to kick start gains and may even be used as a bridge between steroid cycles for maintaining muscle mass and body strength gains.

Dianabol is rated a better option (gram for gram) than Testosterone as Dianabol minimizes affinity of the steroid for sex hormone binding globulin, which is a protein deactivating steroid molecules and capable of inhibiting them from further reactions in the body. In addition to this, Dianabol remains the favorite choice among power lifters and bodybuilders as it helps them increase repetitions during intense workouts and reduces workout fatigue to a significant extent. Dianabol also has the ability to promote the sense of well being and sleep patterns. Dianabol use is also associated with the promotion of calcium deposits in the bones, improving bone strength, and enhancing muscle density while improving endurance capacity.

Recommended Dose Of Dianabol

Male athletes usually use Dianabol in doses of 25-50mg every day while female athletes prefer using Dianabol in doses of 10-20mg every day. Dianabol is ideally stacked with Primobolan, Deca Durabolin, Trenbolone Acetate, Testosterone enanthate or propionate, and Deca Durabolin. Athletes administered with Dianabol should always emphasize on post cycle therapy with Clomid and Nolvadex. This is important for restoring the production of natural testosterone in the body and preventing excess estrogen formation that could have resulted in estrogenic side effects like oily skin, gynecomastia, and acne.

Dianabol is not recommended to those diagnosed with health conditions such as hypertension, high blood pressure, and prostate or breast cancer. It is also not advised to those diagnosed with health conditions such as testicular atrophy, testicular cancer, liver damage, kidney damage, stroke, or respiratory problems. It is also not recommended for children and girls and women, especially those who are pregnant, breastfeeding, or who may get pregnant while using it. Dianabol is also not advised to those who are allergic to its ingredients.

Dianabol should not be overdosed in hopes of quick benefits. The use of Dianabol over extended periods of time should always be avoided as it may lead to liver damage in case of qualified knowledge or lack of appropriate care. Moreover, it should always be purchased from a reputed steroid pharmacy with a valid medical prescription. Abuse or overdosing or use of low grade Dianabol can lead to side effects like male pattern baldness, clitoral hypertrophy, oily skin bouts, and insomnia or difficulty when urinating, edema (swelling), increased aggression, fever, or pain in the lower back (particularly in the kidney areas), and high blood pressure.

Dianabol capsules, pills, or injections should be discarded by taking the advice of a pharmacist or local waste disposal company in case they are not to be used any more or expired.

Bodybuilding Peptide Combinations Guide

Growth Hormone (GH) and IGF-1 are naturally occurring hormones in the human body responsible for many enviable aesthetic traits such as muscle mass, leanness and a firm/even skin tone. As people age, levels of growth hormone rapidly decline and this is one of the main reasons humans put on weight, lose muscle mass and develop sagging/uneven skin. It's no surprise then that synthetic Human Growth Hormone is a sought after product for anti-aging by persons looking to remain youthful, bodybuilders looking to put on muscle mass and people in general who are looking to "tone up" or lose stubborn belly fat.

The following guide indicates the best way to combine different peptides depending on your experience level of diet/training and also your goal:

Fat Loss

The most potent weight loss peptide is HGH Fragment which is the part of the Growth Hormone molecule responsible for fat burning. In HGH Frag Studies, it has been proven to reduce body fat, particularly in the abdominal area. The second most potent fat loss peptide is CJC-1295 DAC since it causes the overall GH level to rise in the body (the opposite of what happens naturally as a person gets older, which is why people tend to put on weight as they age). If your only goal is fat loss, it's often best to avoid the use of GHRP products (GHRP-6, GHRP-2 or Ipamorelin) since they can stimulate hunger and/or raise cortisol, both of which can be counterproductive to fat burning.

Diet Considerations

For GH to exhibit its fat burning effects, insulin must NOT be present. Insulin release in the body is caused mainly by consuming carbohydrates, although all types of macronutrients (carbs, fat and protein) still cause the release of insulin to some extent. Since HGH Fragment 176-191 works by causing the body to break down and release stored fat for use as energy, if you have recently consumed calories (food or beverage) your body will just use that for energy instead and little extra fat will be burnt. If however there is no food present for the body to use as energy, it will use the stored fat which the HGH Fragment 176-191 has caused to be released and you will notice reductions in body fat over the ensuing weeks.

Due to CJC-1295 DAC's long half-life the timing of meals is not important and this is what makes it an appealing addition to HGH Frag 176-191 to accelerate fat loss. To get the most out of your peptide usage for fat loss, the following guidelines should be followed:

• Avoid eating/drinking anything with calories for three (3) hours either side of your injection. 
• Try to make all your meals throughout the day high protein, low fat and low carbohydrates (eg. meat/fish with vegetables/salad). 
• Have as few meals as possible during the day as periods of fasting have been shown in many studies to improve fat loss and also longevity (i.e. eating less will make you live longer).

Sample Peptide Cycles

Beginners

1. HGH Fragment 176-191 at 250-500mcg per day.

Advanced

1. HGH Fragment 176-191 at 250-500mcg per day + CJC-1295 DAC at 300mcg per day or; 
2. HGH Fragment 176-191 at 250-500mcg per day

Example Injection Routines

Example 1 - Night Time Injection (recommended) ◦Ensure you do not eat or drink anything containing calories within three (3) hours of going to bed (with the exception of water, diet sodas, coffee/tea with artificial sweeteners).

• Take your HGH Fragment 176-191 injection just before getting into bed and your body will therefore be burning stored fat for the duration of your sleep. 
• If possible, do some cardio first thing in the morning and wait as long as possible before having breakfast to allow the fat burning to continue throughout the morning/day.

Example 2 - Morning Injection

• Wake up and inject your HGH Fragment 176-191 (250mcg to 500mcg is a good dosage depending on your budget). 
• Wait as long as possible before having your first meal (the longer you wait the more fat you will burn). 
• When you do eat, try to make the meal high protein, low fat and low carbohydrate (example meat and salad/vegetables). 
• If possible, try to do some cardio in the hours after your injection to increase the fat burning effect.

Note: If you are a person concerned about loss of muscle mass, you can consume a small amount of protein every 2-3 hours (amino acid tablets such as EAA and BCAA are good for this purpose and can be purchased from any health food shop or ordered online). However there is little reason to be concerned about muscle loss because when fat is available for energy, such as following HGH Fragment 176-191 injections, protein and therefore muscle mass are spared.

Adding CJC-1295 DAC

You can add CJC-1295 DAC at 2mg once per week (or 300mcg each day along with your HGH Fragment 176-191 injections - they can be mixed in the same syringe without any issues). You should take a break from CJC-1295 DAC every few months to give your pituitary gland a rest at which time you can continue to use HGH Fragment 176-191 on its own.

Muscle Building

Growth Hormone (GH) exhibits its muscle building effects mainly after its conversion to IGF-1 (Insulin-Like-Growth Factor). This makes IGF-1 an ideal choice of peptides for muscle building, especially since the IGF-1 LR3 version has an extended half-life which allows it to remain active in the muscles for many hours to complete its muscle building stimulatory effects. Likewise, if injected after a workout, the IGF-1 variant Mechano Growth Factor (also known as MGF or IGF-1e) is known to multiply muscle cells and contribute to muscle development. Furthermore, since IGF-1 is a by-product of GH, any peptide which increases levels of GH in the body such as a GHRP product or CJC-1295 product will obviously lead to increased lean muscle mass.

Diet Considerations

For Growth Hormone (GH) to perform its anabolic (muscle building) affects it requires the presence of the body's most anabolic hormone: insulin. This is in contrast to GH related fat loss which requires insulin to be absent. However, since GHRP and fast-acting GHRH (Growth Hormone Releasing Hormone) products still need time to stimulate the body to release GH from the pituitary gland, the insulin spike must come after the injection and not before, otherwise the GH release will be blunted.

The only exception to this is of course CJC-1295 DAC since it's long-half life and continual release of GH means it is not affected by food timing.

To get the most out of your peptide usage for muscle building, the following guidelines should be followed:

• If injecting just a GHRP or GHRH product on their own, avoid eating/drinking anything high in fat for 3 hours before your injection and anything high in carbohydrates for 2 hours before (i.e. always do your injection on an empty stomach), otherwise the amount of GH release they cause may be significantly blunted leading to poor results. 
• If injecting both a GHRP and GHRH together (e.g. 100mcg of both GHRP-6 and Modified GRF 1-29) studies have proven that their ability to release GH returns to full-strength as little as 1 hour (60 minutes) post-meal. This gives users greater flexibility with their meal timings, especially since consuming sufficient calories is so critical to building muscle. 
• Whether injecting GH peptides alone or along with others, always wait at least 20 minutes after your injection before consuming anything. Once at least 20 minutes has passed, consume a food/beverage high in protein and/or carbohydrates to stimulate an insulin spike (if you inject in the morning and around your workout, this meal/shake should be high protein and high carbohydrates, if you inject at night this consumption should be protein only as protein is sufficient enough to spike insulin, but without the negative impact on fat gain which carbohydrates can contribute to).

Sample Peptide Cycles

Beginners

1. CJC-1295 DAC at 2mg per week or;
2. GHRP Product  at 200mcg once per day.

Intermediate

1. GHRP Product at 200mcg (2 times per day) or; 
2. GHRP Product at 200mcg + CJC-1295 DAC at 100mcg per day (2 times per day).

Advanced

1. GHRP Product at 200mcg + CJC-1295 DAC at 100mcg (2 times per day) + IGF-1 at 50mcg after workouts or; 
2. GHRP Product at 200mcg + Mod. GRF 1-29 at 100mcg (2 times per day) after workouts.

Example Injection Routines

Beginners

CJC-1295 DAC

• 2mg taken once per week, at any time of day.

GHRP + GHRH (once per day)

• Inject your dosage (ensuring you have not consumed any food/beverages for at least 1 hour before, an optimal time would be first thing in the morning). 
• Ingest a protein only or protein and carbohydrate meal afterward to create an insulin spike. 
• Do weight training in the hours afterwards.

Intermediate

GHRP + GHRH (twice per day)

• Inject your GHRP + GHRH peptides together in the same syringe (ensuring you have not consumed any food/beverages for at least 1 hour before, an optimal time would be first thing in the morning). 
• Ingest a protein only or protein and carbohydrate meal afterward to create an insulin spike. 
• Do weight training in the hours afterwards. ◦at least 1 hour after your dinner (or last meal of the day), take your second GHRP + GHRH injection. 
• If you are trying to control your body fat then have a protein only meal 20-30 minutes afterwards, otherwise a protein/carbohydrate meal will create a better insulin spike.

Advanced

GHRP + GHRH + IGF-1

Follow the same routine as shown above for "intermediate" persons. However, as soon as possible after your weight training you should also inject  50mcg of IGF-1 LR3 preferably into a muscle (although due to the long half-life of both products, sub-q injections are also acceptable). If injecting intramuscularly, you should make sure that the muscle you are injecting into is not covered by a thick layer of fat. Usually due to the length of insulin syringe needles, injections are therefore limited to the biceps for most persons.

While GHRP + GHRH can be injected each day with great benefit, even if you don't do weight training on that day. On the other hand, IGF-1 LR3  should be reserved for post-workout only.

Anti-Aging

For the Anti-Aging crowd, we recommend choosing only 1 peptide, rather than a combination. The reason for this is that as you get older your GH levels decline rapidly and therefore you will benefit from any kind of GH increase meaning there is no need to overdo things with multiple peptides. If you wish to use more than one peptide, we recommend cycling a GHRP product every 3-6 months with CJC-1295 DAC for two reasons.

The first reason is that CJC-1295 DAC is a GHRH (growth hormone releasing hormone) acting directly at the pituitary, while GHRP products indirectly stimulate GH by causing the release of Ghrelin. Rotating the products would therefore ensure one method of GH stimulation does not get "worn out" from repeated exposure to the peptides. The second reason is that even though CJC-1295 DAC has been proven safe in much higher dosages than we recommend, since it causes a continual GH release (GH bleed) no one can be certain how continual use would affect the pituitary in the long-term, so it's a case of being "better safe than sorry" and never using it for longer than 6 months at a time without a break.

Diet Considerations

For CJC-1295 DAC there are no particular diet restrictions that need to be followed due to its long half-life. For GHRP products the following should be observed as insulin and fatty acids can blunt the release of GH in the body and therefore make your injections less effective:
•Avoid eating/drinking anything high in fat for 3 hours before your injection and anything high in carbohydrates for 1-2 hours (always do your injection on an empty stomach). •Wait at least 20 minutes after your injection before eating/drinking anything with calories.

Injection Amounts

1. CJC-1295 DAC taken at 2000mcg (2mg) once per week or; 
2. GHRP Product (GHRP-2, GHRP-6 or Ipamorelin) taken at 200mcg per day.

Example Injection Routines

CJC-1295 DAC

• 2mg taken once per week, at any time of day.

GHRP-2, GHRP-6 or Ipamorelin

Example 1 - Night Time Injection (recommended to reduce possible tiredness during day).

• Ensure you have an empty stomach (i.e. 2-3 hours since your last meal). 
• Inject your GHRP peptide and go straight to bed.

Example 2 - Morning injection

• Take your injection of the GHRP product first thing in the morning at 100mcg. 
• Wait at least 20 minutes before having breakfast or any beverages (including coffee/tea).

Letrozole by QD Labs

Letrozole is a type II (non-steroidal) third generation aromatase inhibitor. Clinically it is used to treat postmenopausal women with either estrogen receptor positive or estrogen receptor unknown breast cancer.

In women, tumors that contain estrogen receptors are classified as estrogen receptor-positive (ER+) tumors. For Letrozole to be prescribed, a given tumor must have been diagnosed as estrogen receptor positive or estrogen receptor unknown.

In the world of bodybuilding it is used to reduce or eliminate excess estrogen caused by the use of aromatizing steroids.

Letrozole is known as a type II aromatase inhibitor, meaning, in simplest terms that it attaches to the aromatase enzyme and prevents it from converting androgens to estrogen. In slightly more complex terms, estrogens are produced by the conversion of androgens through the activity of the aromatase enzyme, and letrozole actually inhibits the production of estrogens in by competitive, (reversible) binding to the heme of the relevant cytochrome P450 unit.

Letrozole is currently the most powerful aromatase inhibitor available. In women with breast cancer, it has been shown to reduce estrogen levels by 98% or more. However, it’s use and benefits are not limited to eliminating estrogen in women.

In one male test subject Letrozole was able to reduce estrogen levels to undetectable levels, and in another clinical study done on both young and elderly men, intravenous administration of Letrozole lowered Estrogen by 46% in the young men tested, and 62% in the elderly subjects. Because estrogen is part of the negative feedback loop of the HPTA, Letrozole (and other anti-estrogens) are able to raise testosterone in male subjects. Letrozole was studied in men, and found to significantly increase LH levels to a 339 and 323% in the young and the elderly, respectively and Testosterone by 146 and 99%, respectively. Letrozole was also able to produce a peak LH response to Gonadatropin Releasing Hormone equal to a 152 and 52% increase from baseline in either young or older men, respectively. In a similar study 0.02 mg of Letrozole increased testosterone by 45% after 2 days. That same twenty micrograms of Letrozole was also enough, in one study done on men, to reduce estrogen levels by roughly a third.

Letrozole has a 2-4 day half-life, and it needs to be taken for up to 60 days to get a steady blood plasma level. Letrozole was used in a rodent study to effectively destroy (benign) breast tissue tumors, which may potentially indicate its use in males attempting to remove gynecomastia (aka gyno). As estrogen is also a factor in stopping linear bone growth, Letrozole is currently being examined for potential use in delay of growth seen in children.

In the world of bodybuilding where more is often thought to be better, Letrozole stands almost alone as an exception to that rule. Estrogen is necessary for healthy immune function, healthy cholesterol levels, joint health, cognitive function, and even aids in muscle growth. In my own experience as well as the experience of many bodybuilders and athletes I’ve worked with, Letrozole simply causes estrogen to be reduced to levels too low to function properly. Personally, I suffered a near career-ending knee injury while using 2.5mgs a day of this stuff, and had one of the worst (and longest) bout with the flu I’ve ever had. In my own particular case, I had been using it to eliminate gyno (which it did). I started at a dose of 2.5mgs/day and reduced it by 25mgs every week until the gyno showed no signs of coming back. Unfortunately, this compromised my immune system and joint integrity.

For most recreational steroid users, Letrozole is going to be too harsh, and cause too many problems. Still, people can use it effectively if they don’t use the manufacturer’s clinical dose (2.5mgs) and instead keep their dose to .25-1mg. There are, however, better choices for an anti-estrogen. I should mention that using Letrozole at such a low dose does happen to make it a very good economic choice compared with other aromatase inhibitors.

For pre-contest bodybuilders, Letrozole is almost a necessity to eliminate water retention and achieve the ripped look necessary to compete in today’s bodybuilding world. However, in my experience, it is only necessary to be used for the last 4-6 weeks, to eliminate excess estrogen and water retention. After using Letrozole I recommend staying away from any estrogen suppression for at least a month to try to normalize the body.